解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specif...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485664
更新日期:2018-01-01 00:00:00
abstract::We present a rare case of IgA nephropathy in a patient who developed atypical hemolytic uremic syndrome (aHUS) associated with a complement factor H (CFH) gene mutation, and who was successfully treated with eculizmab. A 76-year-old man was admitted as the patients had thrombotic microangiopathies findings. The patien...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485194
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000471814
更新日期:2017-01-01 00:00:00
abstract::Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000450895
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper e...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000458417
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. OBJECTIVES AND METHOD:Following a prospective, multicenter, observational design, we studied 237 patients who were tre...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000458418
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Diastolic dysfunction (DD) and low levels of thyroid hormones (TH) are frequent found in chronic kidney disease; both are associated with all-cause and cardiovascular mortality. However, a link between them has not yet been established. The aim of this study was to analyze DD as a surrogate marker of fi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452342
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000456016
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Vancomycin is usually administered after the dialysis sessions to patients undergoing hemodialysis. Administration of vancomycin during (as opposed to after) sessions would save time, and would be more acceptable to patients and staff, but may lead to vancomycin underexposure. The aim of this study was to pr...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000453005
更新日期:2017-01-01 00:00:00
abstract::Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat in...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000477218
更新日期:2017-01-01 00:00:00
abstract::End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000474960
更新日期:2017-01-01 00:00:00
abstract::Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent fo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000450862
更新日期:2017-01-01 00:00:00
abstract::Forced migration is on the rise, mainly from the Middle East to western countries, resulting in unprecedented moral, political, and economic challenges for both refugees and host communities. Recent research showed that refugees represent around 1.5% of the dialysis population in several European and Middle Eastern co...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000477362
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Depression is the most common mental health disorder among those with end-stage renal disease (ESRD), with prevalence of 15-40%. However, the association between chronic kidney disease (CKD) and depression is more variable. We examined the associations of CKD with depression, perceived health status, and qua...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000455750
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) patients who experience superimposed acute kidney injury (AKI) have been shown to be at higher risk of long-term sequelae of AKI when compared to those who do not experience AKI. It remains unclear whether the need for temporary dialysis intervention following superimposed AKI in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000455749
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452810
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448291
更新日期:2017-01-01 00:00:00
abstract::Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000478991
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The epithelial-mesenchymal transition (EMT) is a crucial event in the development of renal interstitial fibrosis (RIF). A growing body of evidence indicates that β-catenin plays an important role in various types of fibrosis. Although members of the microRNA (miRNA)-200 family have been suggested to suppress...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000479168
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:De novo expression of CD44 is considered as a marker of parietal epithelial cell (PEC) activation. The aim of our study was to explore CD74 expression, which can form a complex with CD44, in PECs during the progression of focal segmental glomerulosclerosis (FSGS). To clarify the role of CD74 expression ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448221
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Fatigue is a common symptom in patients receiving hemodialysis (HD) and is generally associated with anemia. However, it can be difficult to resolve, even when anemia has been treated using erythropoiesis-stimulating agents and iron replacement therapy. In the present study, we examined the associations...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448108
更新日期:2016-01-01 00:00:00
abstract::World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, wit...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000444461
更新日期:2016-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000447068
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000443845
更新日期:2016-01-01 00:00:00
abstract::Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide avai...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000445171
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is a cause of biopsy-proven acute kidney injury, more common in the elderly. Treatment requires immunosuppression, which can have significant toxic effects. The aim of this study was to assess whether morbidity and mortality that are a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000447018
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Cyst infection is one of the complications of autosomal dominant polycystic kidney disease and polycystic liver disease. The diagnosis is typically made on a mix of clinical, laboratory and imaging abnormalities but the importance of individual items is uncertain. We aimed to perform a Delphi survey amongst ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000446664
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Anemia management in chronic hemodialysis (HD) has been affected by the implementation of the prospective payment system (PPS) and changes in clinical guidelines. These factors could impact red blood cell (RBC) transfusion in HD patients. Our distinctive care system contains complete records for all RBC tran...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000445447
更新日期:2016-01-01 00:00:00
abstract::In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000444823
更新日期:2016-01-01 00:00:00
abstract:AIMS:There is a trend toward deferring the initiation of chronic dialysis until absolutely indicated. This strategy, however, might lead to increased uncertainties in the timing of dialysis access creation prior to dialysis onset for patients approaching end-stage renal disease (ESRD), and the impact of which on hard e...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000442168
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a cytokine which plays an important role in the division, proliferation and migration of endothelial cells. In the kidney, VEGF expression is found in glomerular podocytes and in tubular epithelial cells, which may result in acute inflammatory reactions. METHODS:...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368700
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Bleeding is the most frequent complication of kidney biopsy. Although bleeding risk in patients with AA amyloidosis after kidney biopsy has not been studied in a large population, AA amyloidosis has long been perceived as a risk factor for bleeding. The aim of the present study was to evaluate post-biopsy bl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000437443
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:In an attempt to decrease mortality in patients with end-stage renal disease, an increase in the lifetime of these patients without much focus on health-related quality of life (HRQOL) was pursued for a long period of time. However, lately, an improvement in the quality of this extended lifetime has focuse...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000369139
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Tolvaptan, a vasopressin V2 receptor antagonist, promotes the excretion of electrolyte-free water. Patients with heart failure or liver cirrhosis, whose urine osmolarity is high due to increased vasopressin, show a good response to tolvaptan; however, it remains dubious whether tolvaptan is also effecti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000381859
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000371448
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368413
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Glucose degradation products (GDPs) in peritoneal dialysis (PD) solution (PDS) have been shown to inflict damage to the kidney, which is the major organ for advanced glycosylation end product elimination. Hence, this study investigated whether new PDSs with neutral pH and low-GDPs have a beneficial effect on...
journal_title:Nephron
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000368235
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000435790
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets ...
journal_title:Nephron
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000430849
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Outcomes in patients treated with haemodialysis(HD) are potentially influenced by the delivered dose of dialysis. The UK Renal Association publishes clinical practice guidelines recommendations for dialysis dose. The urea reduction ratio (URR) is a widely used measure of dialysis dose and has been historical...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000370276
更新日期:2015-01-01 00:00:00